TECNOLOGIA FARMACEUTICA, VEICOLAZIONE E DIREZIONAMENTO DEI FARMACI

Module VEICOLAZIONE E DIREZIONAMENTO DEI FARMACI

The aim of this course is to provide the student with knowledge and expertise about the strategies exploited in the field of drug-modified release and targeting and their use in biotechnology. In addition, the course focuses on fundamentals of biopharmaceutics and their application to pharmaceutical technology to provide the student with a comprehensive understanding of controlled drug delivery systems.  

Frontal lessons (5CFU) and laboratory activities in groups (1 CFU). Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Information for students with disabilities and / or SLD

To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the Department of Biomedical and Biotechonological Sciences.

Basic knowledge of organic chemistry and pharmaceutical technology.

Attendance is mandatory. It is gained attending at least 70% of lessons.

Administration routes and bioavailability of drugs. Controlled drug delivery systems: classification. Active and passive drug targeting. Fundamentals of controlled drug delivery systems: reservoir systems, osmotic systems, matrix systems, ion exchange systems.

Vesicular controlled delivery systems. Liposomes: advantages and limits, classification, preparation methods, physico-chemical and technological characterization, use in the pharmaceutical field. Ethosomes, transferosomes, niosomes. Technological properties and use in the pharmaceutical field.

Microparticles as controlled delivery systems: advantages and limits. Preparation and characterization methods. Use in the pharmaceutical field.

Nanoparticles as controlled delivery systems: polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers. Advantages and limits. Physico-chemical and technological characterization. Preparation methods. Use in the pharmaceutical field.

Chemically controlled delivery systems: prodrugs. Advantages and limits, properties and use in the pharmaceutical field.

Molecular inclusion complexes: cyclodextrins. Definition and classification. Preparation methods of cyclodextrin-drug inclusion complexes. Instrumental analyses to characterize inclusion complexes. Use in the pharmaceutical field.

Transdermal delivery systems: advantages and limits, technological properties, use in the pharmaceutical field.

Gene therapy: fundamentals and goals. Biological barriers to gene delivery. DNA and the oligonucleotide delivery: viral and synthetic carriers (liposomes, cationic polymers and lipopolyplexes).

1. COLOMBO P., CATELLANI P.L., GAZZANIGA A., MENEGATTI E., VIDALE E.; Principi di tecnologie Farmaceutiche; Casa Ed. Ambrosiana, Ultima Edizione.

2. FLORENCE A.T. AND ATTWOOD D.; Le basi chimico-fisiche della Tecnologia Farmaceutica; Edises, Ultima Edizione.

3. AULTON M.E. AND TAYLOR K.M. Tecnologie farmaceutiche. Progettazione e allestimento dei medicinali; Edra, Ultima Edizione1.1

Learning assessment is performed in the form of written test consisting of 5 open questions.  The exam lasts two hours.

Learning assessment may also be carried out on line, should the conditions require it.

1. Preparation methods used for liposomes

2. Advantages and limits of drug transdermal administration

3. Technological properties of solid lipid nanoparticles

4. Use of liposomes in gene therapy

5. Microparticles as drug carriers