BIOLOGIA MOLECOLARE E BIOLOGIA MOLECOLARE AVANZATA M - ZModule BIOLOGIA MOLECOLARE AVANZATA
Academic Year 2023/2024 - Teacher: Vito Nicola DE PINTOExpected Learning Outcomes
Students will be given a clear overview of the molecular mechanisms underlying the regulation of transcription in the human genome, as well as the fundamental role of microRNAs and long-noncoding RNAs in the control mechanisms of biological functions. Students will be able to link the structure with the function of molecules, and thus with complex biological phenomena.
They will also be provided with knowledge of the experimental tools that make modern advances in scientific research possible.
They will also be provided with knowledge of the experimental tools that make modern advances in scientific research possible.
Course Structure
Lectures supported by slides in ppt format that will be made available to students on the STUDIUM platform.
Required Prerequisites
Knowledge of General Biochemistry and Basic Molecular Biology.
Attendance of Lessons
Course attendance is mandatory to the extent provided for in the course regulations
Detailed Course Content
- The regulation of transcription in eukaryotes
- The ENCODE project and the regulation of transcription in the human genome.
- Non-coding RNA, the black matter of molecular biology: lncRNA, siRNA, miRNA and piRNA
- The regulation of translation
- DNA recombination: homologous, site-specific and transposition
- DNA repair: DNA damage and repair mechanisms
- The ENCODE project and the regulation of transcription in the human genome.
- Non-coding RNA, the black matter of molecular biology: lncRNA, siRNA, miRNA and piRNA
- The regulation of translation
- DNA recombination: homologous, site-specific and transposition
- DNA repair: DNA damage and repair mechanisms
Textbook Information
Zlatanova & van Holde, Biologia Molecolare: Struttura e dinamica dei Genomi e Proteomi, Zanichelli 2018.
Watson, J.D. et al., Biologia Molecolare del gene VII ed., Zanichelli 2015
Learning Assessment
Learning Assessment Procedures
There will be a written test and/or an oral interview on all course topics
Examples of frequently asked questions and / or exercises
Role of microRNAs in the regulation of gene expression.
Differences in the regulation of transcription between bacteria and eukaryotes.
Principles of techniques adopted in the ENCODE project
VERSIONE IN ITALIANO
Differences in the regulation of transcription between bacteria and eukaryotes.
Principles of techniques adopted in the ENCODE project